4-Methoxybenzylzinc chloride solution 0.5 in THF - Names and Identifiers
4-Methoxybenzylzinc chloride solution 0.5 in THF - Physico-chemical Properties
Molecular Formula | C8H9ClOZn
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Molar Mass | 222 |
Density | 0.958g/mLat 25°C |
Flash Point | 1°F |
Storage Condition | 2-8°C |
4-Methoxybenzylzinc chloride solution 0.5 in THF - Risk and Safety
Risk Codes | R19 - May form explosive peroxides
R22 - Harmful if swallowed
R36/38 - Irritating to eyes and skin.
R40 - Limited evidence of a carcinogenic effect
R36/37 - Irritating to eyes and respiratory system.
R11 - Highly Flammable
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Safety Description | S16 - Keep away from sources of ignition.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S33 - Take precautionary measures against static discharges.
S36 - Wear suitable protective clothing.
S36/37 - Wear suitable protective clothing and gloves.
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UN IDs | UN 2056 3/PG 2 |
WGK Germany | 1 |
4-Methoxybenzylzinc chloride solution 0.5 in THF - Introduction
4-Methoxybenzylzinc chloride(4-Methoxybenzylzinc chloride) is an organic zinc compound. Its chemical formula is C8H9ClOZn and its molecular weight is 213.46. The compound has the following properties:
1. Appearance: 4-Methoxybenzylzinc chloride is a white to light yellow solid.
2. Solubility: It is soluble in some organic solvents (such as ethers and alkanes), but not soluble in water.
The 4-Methoxybenzylzinc chloride has multiple applications:
1. Organic synthesis: It can be used as a conjugate addition reagent of olefins and participate in various organic synthesis reactions, such as Michael addition, Suzuki coupling, etc.
2. Catalyst: It can also be used as a catalyst for some organic reactions, such as asymmetric synthesis and C- H activation.
The method for preparing 4-Methoxybenzylzinc chloride is as follows:
First, benzyl magnesium bromide (PhMgBr) needs to be reacted with 4-Methoxybenzeneboronic acid (4-Methoxybenzeneboronic acid) to generate 4-methoxybenzylbenzyl magnesium (chloride). 4-Methoxybenzylbenzyl magnesium is then reacted with zinc chloride to produce 4-Methoxybenzylzinc chloride.
Regarding safety information, 4-Methoxybenzylzinc chloride should pay attention to the following when operating:
1. toxicity: 4-Methoxybenzylzinc chloride is an organometallic compound, which may be toxic to human body. Proper operating procedures should be followed to prevent contact with skin, eyes and respiratory tract.
2. Flammability: The compound is a flammable substance and needs to be stored in a cool and ventilated place, and stored separately from the oxidant.
3. Personal protection: During operation, you should wear appropriate personal protective equipment, such as gloves, protective glasses and protective masks.
in the use of 4-Methoxybenzylzinc chloride, should strictly follow the safety procedures, and consult the guidance of professionals. At the same time, pay attention to mixing with other chemicals to avoid dangerous reactions.
Last Update:2024-04-10 22:29:15